Increased parity and risk of trisomy 21
نویسندگان
چکیده
منابع مشابه
Risk factors for nondisjunction of trisomy 21.
The leading cause of Down syndrome (DS) is nondisjunction of chromosome 21 occurring during the formation of gametes. In this review, we discuss the progress made to identify risk factors associated with this type of chromosome error occurring in oogenesis and spermatogenesis. For errors occurring in oocytes, the primary risk factors are maternal age and altered recombination. We review the cur...
متن کاملTrisomy 21 and Risk of Retinopathy of Prematurity.
BACKGROUND AND OBJECTIVES Trisomy 21 is known to decrease the risk of several (nonocular) angiogenic-mediated diseases. The objective of this study was to determine whether trisomy 21 can also be shown to be significantly protective against ocular angiogenic-mediated disorders such as retinopathy of prematurity (ROP). METHODS A retrospective analysis of deidentified data from the Pediatrix Ba...
متن کاملEchogenic intracardiac foci: associated with increased risk for fetal trisomy 21 or not?
OBJECTIVE The purpose of this study was to evaluate the impact of an echogenic intracardiac focus (EIF) on the risk for fetal trisomy 21 (T21) in populations with differing prevalence of T21. METHODS A retrospective cohort study of pregnancies presenting to our prenatal ultrasound units over 16 years (1990-2006) was conducted. Contingency table analysis of the presence of an EIF and diagnosis...
متن کاملLipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21.
BACKGROUND It has been suggested that an increase in oxidative stress in individuals with Down syndrome (DS) may cause adverse effects in the cell membranes through the oxidation of polyunsatured fatty acids. METHODS We examined erythrocyte malondialdehyde (MDA) levels in 100 individuals of both sexes (34 males and 66 females) with DS, aged from newborn to 29 years. The cytogenetic analysis r...
متن کاملMaternal age- and gestation-specific risk for trisomy 21.
OBJECTIVE To provide estimates of maternal age- and gestational age-related risks for trisomy 21. METHODS The prevalence of trisomy 21 was examined in 57,614 women who had fetal karyotyping at 9-16 weeks of gestation for the sole indication of maternal age of 35 years or more. On the basis of the maternal age distribution and the reported maternal age-related risk for trisomy 21 at birth, the...
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ژورنال
عنوان ژورنال: BMJ
سال: 1997
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.314.7096.1760a